Two sample MR report
SMIM19_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.7065136 | 1.5944679 | 0.7344636 |
| Weighted median | 3 | -0.0476556 | 0.0188786 | 0.0115921 |
| Inverse variance weighted | 3 | -0.0460229 | 0.0147826 | 0.0018500 |
| Simple mode | 3 | -0.0508280 | 0.0214276 | 0.1410674 |
| Weighted mode | 3 | -0.0506372 | 0.0216336 | 0.1440942 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0126090 | 1 | 0.9105935 |
| Inverse variance weighted | 0.2353812 | 2 | 0.8889711 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.3578503 | 0.7581777 | 0.7192587 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.68e-05 | 0 | TRUE | 0.5676858 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
